Therapeutic targeting of HES1 transcriptional programs in T-ALL

Oncogenic activation of NOTCH1 signaling plays a central role in the pathogenesis of T-cell acute lymphoblastic leukemia, with mutations on this signaling pathway affecting more than 60% of patients at diagnosis. However, the transcriptional regulatory circuitries driving T-cell transformation downs...

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Udgivet i:Blood
Main Authors: Schnell, Stephanie A., Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Belver, Laura, Xu, Luyao, Qin, Yue, Kageyama, Ryoichiro, Ferrando, Adolfo A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424629/
https://ncbi.nlm.nih.gov/pubmed/25784680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-608448
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