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Therapeutic targeting of NOTCH1 signaling in T-ALL

The recent identification of activating mutations in NOTCH1 in the majority of T-cell acute lymphoblastic leukemias (T-ALL) has brought major interest towards targeting the NOTCH signaling pathway in this disease. Small molecule γ-secretase inhibitors (GSIs) which block a critical proteolytic step r...

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Autors principals: Palomero, Teresa, Ferrando, Adolfo
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814179/
https://ncbi.nlm.nih.gov/pubmed/19778842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3816/CLM.2009.s.013
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