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Therapeutic targeting of NOTCH1 signaling in T-ALL
The recent identification of activating mutations in NOTCH1 in the majority of T-cell acute lymphoblastic leukemias (T-ALL) has brought major interest towards targeting the NOTCH signaling pathway in this disease. Small molecule γ-secretase inhibitors (GSIs) which block a critical proteolytic step r...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814179/ https://ncbi.nlm.nih.gov/pubmed/19778842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3816/CLM.2009.s.013 |
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