Structure and mechanisms of NT5C2 mutations driving thiopurine resistance in relapsed lymphoblastic leukemia

Activating mutations in the cytosolic 5’-nucleotidase II gene NT5C2 drive resistance to 6-mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively active NT5C2 mutations K359Q and L375F reconfigure the catalytic center for substrate access and catalysis in the absence...

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Détails bibliographiques
Publié dans:Cancer Cell
Auteurs principaux: Dieck, Chelsea L., Tzoneva, Gannie, Forouhar, Farhad, Carpenter, Zachary, Ambesi-Impiombato, Alberto, Sánchez-Martín, Marta, Kirschner-Schwabe, Renate, Lew, Scott, Seetharaman, Jayaraman, Tong, Liang, Ferrando, Adolfo A.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049837/
https://ncbi.nlm.nih.gov/pubmed/29990496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.06.003
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