Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric and over 50% of adult ALL patients fail to achieve a complete remission or relapse after intensified chemother...

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Detalhes bibliográficos
Main Authors: Tzoneva, Gannie, Garcia, Arianne Perez, Carpenter, Zachary, Khiabanian, Hossein, Tosello, Valeria, Allegretta, Maddalena, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M., Tallman, Martin S., Paganin, Maddalena, Basso, Giuseppe, Hof, Jana, Kirschner-Schwabe, Renate, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594483/
https://ncbi.nlm.nih.gov/pubmed/23377281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3078
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