Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

gan Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Cyhoeddwyd yn Sci Adv (2017)

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

gan Aksel, Tural, Yu, Elizabeth Choe, Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Cyhoeddwyd yn Cell Rep (2015)

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

gan Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.
Cyhoeddwyd yn Biophys Rev (2017)

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

gan Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M.
Cyhoeddwyd 2013

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

gan Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Cyhoeddwyd yn Nat Struct Mol Biol (2017)

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

gan Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Pasha, Shaik N., Ruppel, Kathleen M., Spudich, James A.
Cyhoeddwyd yn Sci Adv (2020)

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

gan Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Cyhoeddwyd yn Nat Commun (2019)

Essential role for Gα(13) in endothelial cells during embryonic development

gan Ruppel, Kathleen M., Willison, David, Kataoka, Hiroshi, Wang, Alice, Zheng, Yao-Wu, Cornelissen, Ivo, Yin, Liya, Xu, Shan Mei, Coughlin, Shaun R.
Cyhoeddwyd 2005

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin

gan Pan, Stephen, Sommese, Ruth F., Sallam, Karim I., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M., Ashley, Euan A.
Cyhoeddwyd yn BMC Med Genet (2015)

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

gan Nag, Suman, Sommese, Ruth F., Ujfalusi, Zoltan, Combs, Ariana, Langer, Stephen, Sutton, Shirley, Leinwand, Leslie A., Geeves, Michael A., Ruppel, Kathleen M., Spudich, James A.
Cyhoeddwyd yn Sci Adv (2015)

Dilated cardiomyopathy myosin mutants have reduced force-generating capacity

gan Ujfalusi, Zoltan, Vera, Carlos D., Mijailovich, Srbolujub M., Svicevic, Marina, Yu, Elizabeth Choe, Kawana, Masataka, Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Cyhoeddwyd yn J Biol Chem (2018)

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

gan Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Cyhoeddwyd yn J Biol Chem (2019)

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

gan Spudich, James A., Aksel, Tural, Bartholomew, Sadie R., Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S., Sung, Jongmin, Sommese, Ruth F., Sutton, Shirley, Cho, Carol, Adhikari, Arjun S., Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M.
Cyhoeddwyd yn J Exp Biol (2016)

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

gan Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2021)

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

gan Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2018)

Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness

gan Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András
Cyhoeddwyd yn Cell (2020)

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

gan Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2016)