Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Por Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Publicado no Sci Adv (2017)

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Por Aksel, Tural, Yu, Elizabeth Choe, Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Publicado no Cell Rep (2015)

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

Por Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.
Publicado no Biophys Rev (2017)

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

Por Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M.
Publicado em 2013

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Por Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Publicado no Nat Struct Mol Biol (2017)

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Por Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Pasha, Shaik N., Ruppel, Kathleen M., Spudich, James A.
Publicado no Sci Adv (2020)

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Por Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Publicado no Nat Commun (2019)

Essential role for Gα(13) in endothelial cells during embryonic development

Por Ruppel, Kathleen M., Willison, David, Kataoka, Hiroshi, Wang, Alice, Zheng, Yao-Wu, Cornelissen, Ivo, Yin, Liya, Xu, Shan Mei, Coughlin, Shaun R.
Publicado em 2005

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin

Por Pan, Stephen, Sommese, Ruth F., Sallam, Karim I., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M., Ashley, Euan A.
Publicado no BMC Med Genet (2015)

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

Por Nag, Suman, Sommese, Ruth F., Ujfalusi, Zoltan, Combs, Ariana, Langer, Stephen, Sutton, Shirley, Leinwand, Leslie A., Geeves, Michael A., Ruppel, Kathleen M., Spudich, James A.
Publicado no Sci Adv (2015)

Dilated cardiomyopathy myosin mutants have reduced force-generating capacity

Por Ujfalusi, Zoltan, Vera, Carlos D., Mijailovich, Srbolujub M., Svicevic, Marina, Yu, Elizabeth Choe, Kawana, Masataka, Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Publicado no J Biol Chem (2018)

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Por Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Publicado no J Biol Chem (2019)

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

Por Spudich, James A., Aksel, Tural, Bartholomew, Sadie R., Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S., Sung, Jongmin, Sommese, Ruth F., Sutton, Shirley, Cho, Carol, Adhikari, Arjun S., Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M.
Publicado no J Exp Biol (2016)

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Por Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Publicado no Proc Natl Acad Sci U S A (2018)

Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness

Por Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András
Publicado no Cell (2020)

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

Por Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
Publicado no Proc Natl Acad Sci U S A (2016)