Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

Hypertrophic cardiomyopathy (HCM) is the most frequently occurring inherited cardiovascular disease. It is caused by mutations in genes encoding the force-generating machinery of the cardiac sarcomere, including human β-cardiac myosin. We present a detailed characterization of the most debated HCM-c...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Nag, Suman, Sommese, Ruth F., Ujfalusi, Zoltan, Combs, Ariana, Langer, Stephen, Sutton, Shirley, Leinwand, Leslie A., Geeves, Michael A., Ruppel, Kathleen M., Spudich, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646805/
https://ncbi.nlm.nih.gov/pubmed/26601291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500511
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