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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise...
Enregistré dans:
| Publié dans: | Sci Adv |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Association for the Advancement of Science
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302870/ https://ncbi.nlm.nih.gov/pubmed/28246639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601959 |
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