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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Adv
Päätekijät: Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Association for the Advancement of Science 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302870/
https://ncbi.nlm.nih.gov/pubmed/28246639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601959
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