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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise...

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書誌詳細
出版年:Sci Adv
主要な著者: Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302870/
https://ncbi.nlm.nih.gov/pubmed/28246639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601959
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