Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Cardiovascular disorders are the leading cause of morbidity and mortality in the developed world, and hypertrophic cardiomyopathy (HCM) is among the most frequently occurring inherited cardiac disorders. HCM is caused by mutations in the genes encoding the fundamental force-generating machinery of t...

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Detalhes bibliográficos
Main Authors: Sommese, Ruth F., Sung, Jongmin, Nag, Suman, Sutton, Shirley, Deacon, John C., Choe, Elizabeth, Leinwand, Leslie A., Ruppel, Kathleen, Spudich, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732973/
https://ncbi.nlm.nih.gov/pubmed/23798412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309493110
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