Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β-cardiac myosin heavy chain gene (β-MyHC) are a major cause of HCM, but the specific mechanistic changes to myosin function that lead to thi...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873187/
https://ncbi.nlm.nih.gov/pubmed/31582565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010563
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