Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment f...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2021
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214707/
https://ncbi.nlm.nih.gov/pubmed/34117120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025030118
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