Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for uncovering disease mechanisms and assessing drugs for efficacy/toxicity. However, the accuracy with which hiPSC-CMs recapitulate the contractile and remodeling signaling of adult cardiomyocytes is not...

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Vydáno v:FASEB J
Hlavní autoři: Jung, Gwanghyun, Fajardo, Giovanni, Ribeiro, Alexandre J. S., Kooiker, Kristina Bezold, Coronado, Michael, Zhao, Mingming, Hu, Dong-Qing, Reddy, Sushma, Kodo, Kazuki, Sriram, Krishna, Insel, Paul A., Wu, Joseph C., Pruitt, Beth L., Bernstein, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799510/
https://ncbi.nlm.nih.gov/pubmed/26675706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-280982
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