Points: Clinical Algorithms: Compulsory detention in hospital under the Mental Health Act 1983

by Rhode, Peter
Published 1987

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity

by Wong, Hing C, Jeng, Emily K, Rhode, Peter R
Published 2013

Enhanced efficacy of IL-15-based ALT-803 superagonist complex in combination with immune checkpoint inhibitors in hematologic and metastatic mouse tumor models

by Xu, Wenxin, Marcus, Warren D, Rhode, Peter R, Wong, Hing C
Published in J Immunother Cancer (2014)

Evaluation of a novel CD20-targeted IL-15 immunotherapeutic with potent activity against B cell lymphoma

by Liu, Bai, Kong, Lin, Marcus, Warren D, Chen, Xiaoyue, Han, Kaiping, Rhode, Peter R, Wong, Hing C
Published in J Immunother Cancer (2014)

CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma

by Margolin, Kim, Wong, Hing C, Morishima, Chihiro, Hernandez, Liza, Ernstoff, Marc, Rhode, Peter R, Waldmann, Thomas A
Published in J Immunother Cancer (2014)

Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice

by Xu, Wenxin, Kage, Karen, Marcus, Warren D, Newman, Robby, Alter, Sarah, Rhode, Peter R, Wong, Hing C
Published in J Immunother Cancer (2015)

A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distr...

by Morris, Peter E, Steingrub, Jay S, Huang, Bee Y, Tang, Shamay, Liu, Patrick M, Rhode, Peter R, Wong, Hing C
Published 2012

The IL-15 superagonist ALT-803 enhances anti-CD20 antibody-directed NK cell ADCC and in vivo clearance of B cell lymphomas

by Rosario, Maximillian, Liu, Bai, Kong, Lin, Schneider, Stephanie E, Jeng, Emily K, Rhode, Peter R, Wong, Hing C, Fehniger, Todd A
Published in J Immunother Cancer (2014)

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

by Furuya, Hideki, Chan, Owen T. M., Pagano, Ian, Zhu, Chengjun, Kim, Nari, Peres, Rafael, Hokutan, Kanani, Alter, Sarah, Rhode, Peter, Rosser, Charles J.
Published in J Transl Med (2019)

Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syng...

by Chen, Xiaoyue, Liu, Bai, Han, Kaiping, Kong, Lin, Noel, Terra, Jeng, Emily K, Alter, Sarah, Rubinstein, Mark, Rhode, Peter R, Wong, Hing C
Published in J Immunother Cancer (2015)

Novel Human Interleukin-15 Agonists

by Zhu, Xiaoyun, Marcus, Warren D., Xu, Wenxin, Lee, Hyung-Il, Han, Kaiping, Egan, Jack O., Yovandich, Jason L., Rhode, Peter R., Wong, Hing C.
Published 2009

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

by Mathios, Dimitrios, Park, Chul-Kee, Marcus, Warren D., Alter, Sarah, Rhode, Peter R., Jeng, Emily K., Wong, Hing C., Pardoll, Drew M., Lim, Michael
Published in Int J Cancer (2015)

Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models

by Liu, Bai, Jones, Monica, Kong, Lin, Noel, Terra, Jeng, Emily K., Shi, Sixiang, England, Christopher G., Alter, Sarah, Miller, Jeffrey S., Cai, Weibo, Rhode, Peter R., Wong, Hing C.
Published in Cytokine (2018)

Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells

by Xu, Wenxin, Egan, Jack O, Liu, Bai, Chen, Xiaoyue, You, Lijing, Han, Kaiping, Marcus, Warren D, Kong, Lin, Jones, Monica, Jeng, Emily K, Rhode, Peter R, Wong, Hing C
Published in J Immunother Cancer (2014)

Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules

by Wong, Richard L., Liu, Bai, Zhu, Xiaoyun, You, Lijing, Kong, Lin, Han, Kai-Ping, Lee, Hyung-il, Chavaillaz, Pierre-Andre, Jin, Moonsoo, Wang, Yi, Rhode, Peter R., Wong, Hing C.
Published 2011

Phase 1 trial of ALT-801, an interleukin-2/T cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies

by Fishman, Mayer N., Thompson, John A., Pennock, Gregory K., Gonzalez, Rene, Diez, Luz M., Daud, Adil I., Weber, Jeffery S., Huang, Bee Y., Tang, Shamay, Rhode, Peter R., Wong, Hing C.
Published 2011

Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

by Gomes-Giacoia, Evan, Miyake, Makito, Goodison, Steve, Sriharan, Aravindhan, Zhang, Ge, You, Lijing, Egan, Jack O., Rhode, Peter R., Parker, Alexander S., Chai, Karl X., Wong, Hing C., Rosser, Charles J.
Published 2014

IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization

by Han, Kai-ping, Zhu, Xiaoyun, Liu, Bai, Jeng, Emily, Kong, Lin, Yovandich, Jason L., Vyas, Vinay V., Marcus, Warren D., Chavaillaz, Pierre-Andre, Romero, Christian A., Rhode, Peter R., Wong, Hing C.
Published 2011

Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor α/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma

by Xu, Wenxin, Jones, Monica, Liu, Bai, Zhu, Xiaoyun, Johnson, C. Bryce, Edwards, Ana C., Kong, Lin, Jeng, Emily K., Han, Kaiping, Marcus, Warren D., Rubinstein, Mark P., Rhode, Peter R., Wong, Hing C.
Published 2013

A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses

by Liu, Bai, Kong, Lin, Han, Kaiping, Hong, Hao, Marcus, Warren D., Chen, Xiaoyue, Jeng, Emily K., Alter, Sarah, Zhu, Xiaoyun, Rubinstein, Mark P., Shi, Sixiang, Rhode, Peter R., Cai, Weibo, Wong, Hing C.
Published in J Biol Chem (2016)