Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models

ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8(+) T cell proliferation and activation, and effectively...

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Detalhes bibliográficos
Publicado no:Cytokine
Main Authors: Liu, Bai, Jones, Monica, Kong, Lin, Noel, Terra, Jeng, Emily K., Shi, Sixiang, England, Christopher G., Alter, Sarah, Miller, Jeffrey S., Cai, Weibo, Rhode, Peter R., Wong, Hing C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916319/
https://ncbi.nlm.nih.gov/pubmed/29452720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2017.12.003
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