Why is immunotherapy for glioblastoma “Lag”-ging

per Mathios, Dimitrios, Lim, Michael
Publicat a Oncotarget (2019)

New Prospects for Molecular Targets for Chordomas

per Ozair, Mohammad Zeeshan, Shah, Pavan, Mathios, Dimitrios, Lim, Michael, Moss, Nelson S.
Publicat a Neurosurg Clin N Am (2020)

Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement

per Eseonu, Chikezie I., Goodwin, C. Rory, Zhou, Xin, Theodros, Debebe, Bender, Matthew T., Mathios, Dimitrios, Bettegowda, Chetan, Lim, Michael
Publicat a J Neurosurg (2015)

IT-21 PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODE...

per Mathios, Dimitrios, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher, Nicholas, Sarah, Tyler, Betty, Pardoll, Drew, Brem, Henry, Lim, Michael
Publicat 2014

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

per Mathios, Dimitrios, Park, Chul-Kee, Marcus, Warren D., Alter, Sarah, Rhode, Peter R., Jeng, Emily K., Wong, Hing C., Pardoll, Drew M., Lim, Michael
Publicat a Int J Cancer (2015)

PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

per Mathios, Dimitrios, Ruzevick, Jacob, Jackson, Christopher M., Xu, Haiying, Shah, Sagar, Taube, Janis M., Burger, Peter C., McCarthy, Edward F., Quinones-Hinojosa, Alfredo, Pardoll, Drew M., Lim, Michael
Publicat a J Neurooncol (2014)

Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model

per Mathios, Dimitrios, Kim, Jennifer, Phallen, Jillian, Mangraviti, Antonella, Park, Chul-Kee, Theodros, Debebe, Jackson, Christopher, Garzon-Muvdi, Tomas, Kim, Eileen, Ye, Xiaobu, Tyler, Betty, Brem, Henry, Pardoll, Drew, Lim, Michael
Publicat a J Immunother Cancer (2015)

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

per Hwang, Taeyoung, Mathios, Dimitrios, McDonald, Kerrie L., Daris, Irene, Park, Sung-Hye, Burger, Peter C., Kim, Sojin, Dho, Yun-Sik, Carolyn, Hruban, Bettegowda, Chetan, Shin, Joo Heon, Lim, Michael, Park, Chul-Kee
Publicat a Acta Neuropathol Commun (2019)

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

per Belcaid, Zineb, Berrevoets, Cor, Choi, John, van Beelen, Edward, Stavrakaki, Eftychia, Pierson, Tessa, Kloezeman, Jenneke, Routkevitch, Denis, van der Kaaij, Mariëlle, van der Ploeg, Alicia, Mathios, Dimitrios, Sleijfer, Stefan, Dirven, Clemens, Lim, Michael, Debets, Reno, Lamfers, Martine L M
Publicat a Neurooncol Adv (2020)

IMPS-20 COMBINATION THERAPY WITH ANTI-PD-1, ANTI-TIM-3, AND FOCAL RADIATION RESULTS IN REGRESSION OF MURINE GLIOMAS

per Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Polanczyk, Magda, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric, Mathios, Dimitrios, Jackson, Christopher M., Olivi, Alessandro, Tran, Phuoc, Drake, Charles G., Tyler, Betty, Ye, Xiaobu, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publicat a Neuro Oncol (2015)

Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

per Mathios, Dimitrios, Kim, Jennifer E., Mangraviti, Antonella, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher M., Garzon-Muvdi, Tomas, Kim, Eileen, Theodros, Debebe, Polanczyk, Magdalena, Martin, Allison M., Suk, Ian, Ye, Xiaobu, Tyler, Betty, Bettegowda, Chetan, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publicat a Sci Transl Med (2016)

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

per Belcaid, Zineb, Phallen, Jillian A., Zeng, Jing, See, Alfred P., Mathios, Dimitrios, Gottschalk, Chelsea, Nicholas, Sarah, Kellett, Meghan, Ruzevick, Jacob, Jackson, Christopher, Albesiano, Emilia, Durham, Nicholas M., Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Wong, John W., Brem, Henry, Pardoll, Drew M., Drake, Charles G., Lim, Michael
Publicat 2014

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

per Maxwell, Russell, Luksik, Andrew S., Garzon-Muvdi, Tomas, Hung, Alice L., Kim, Eileen S., Wu, Adela, Xia, Yuanxuan, Belcaid, Zineb, Gorelick, Noah, Choi, John, Theodros, Debebe, Jackson, Christopher M., Mathios, Dimitrios, Ye, Xiaobu, Tran, Phuoc T., Redmond, Kristin J., Brem, Henry, Pardoll, Drew M., Kleinberg, Lawrence R., Lim, Michael
Publicat a Oncoimmunology (2018)

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

per Harris-Bookman, Sarah, Mathios, Dimitrios, Martin, Allison M., Xia, Yuanxuan, Kim, Eileen, Xu, Haiying, Belcaid, Zineb, Polanczyk, Magdalena, Barberi, Theresa, Theodros, Debebe, Kim, Jennifer, Taube, Janis M., Burger, Peter C., Selby, Mark, Taitt, Corina, Korman, Alan, Ye, Xiaobu, Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Publicat a Int J Cancer (2018)

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

per Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Publicat a Proc Natl Acad Sci U S A (2017)

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

per Hung, Alice L., Maxwell, Russell, Theodros, Debebe, Belcaid, Zineb, Mathios, Dimitrios, Luksik, Andrew S., Kim, Eileen, Wu, Adela, Xia, Yuanxuan, Garzon-Muvdi, Tomas, Jackson, Christopher, Ye, Xiaobu, Tyler, Betty, Selby, Mark, Korman, Alan, Barnhart, Bryan, Park, Su-Myeong, Youn, Je-In, Chowdhury, Tamrin, Park, Chul-Kee, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publicat a Oncoimmunology (2018)

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

per Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Publicat a Proc Natl Acad Sci U S A (2018)

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

per Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Publicat a J Immunother Cancer (2016)

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

per Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Publicat a J Immunother Cancer (2016)

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

per Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric W., Tam, Ada, Xu, Haiying, Mathios, Dimitrios, Jackson, Christopher M., Harris-Bookman, Sarah, Garzon-Muvdi, Tomas, Sheu, Mary, Martin, Allison M., Tyler, Betty M., Tran, Phuoc T., Ye, Xiaobu, Olivi, Alessandro, Taube, Janis M., Burger, Peter C., Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Publicat a Clin Cancer Res (2016)