Why is immunotherapy for glioblastoma “Lag”-ging

par Mathios, Dimitrios, Lim, Michael
Publié dans Oncotarget (2019)

New Prospects for Molecular Targets for Chordomas

par Ozair, Mohammad Zeeshan, Shah, Pavan, Mathios, Dimitrios, Lim, Michael, Moss, Nelson S.
Publié dans Neurosurg Clin N Am (2020)

Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement

par Eseonu, Chikezie I., Goodwin, C. Rory, Zhou, Xin, Theodros, Debebe, Bender, Matthew T., Mathios, Dimitrios, Bettegowda, Chetan, Lim, Michael
Publié dans J Neurosurg (2015)

IT-21 PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODE...

par Mathios, Dimitrios, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher, Nicholas, Sarah, Tyler, Betty, Pardoll, Drew, Brem, Henry, Lim, Michael
Publié 2014

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

par Mathios, Dimitrios, Park, Chul-Kee, Marcus, Warren D., Alter, Sarah, Rhode, Peter R., Jeng, Emily K., Wong, Hing C., Pardoll, Drew M., Lim, Michael
Publié dans Int J Cancer (2015)

PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

par Mathios, Dimitrios, Ruzevick, Jacob, Jackson, Christopher M., Xu, Haiying, Shah, Sagar, Taube, Janis M., Burger, Peter C., McCarthy, Edward F., Quinones-Hinojosa, Alfredo, Pardoll, Drew M., Lim, Michael
Publié dans J Neurooncol (2014)

Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model

par Mathios, Dimitrios, Kim, Jennifer, Phallen, Jillian, Mangraviti, Antonella, Park, Chul-Kee, Theodros, Debebe, Jackson, Christopher, Garzon-Muvdi, Tomas, Kim, Eileen, Ye, Xiaobu, Tyler, Betty, Brem, Henry, Pardoll, Drew, Lim, Michael
Publié dans J Immunother Cancer (2015)

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

par Hwang, Taeyoung, Mathios, Dimitrios, McDonald, Kerrie L., Daris, Irene, Park, Sung-Hye, Burger, Peter C., Kim, Sojin, Dho, Yun-Sik, Carolyn, Hruban, Bettegowda, Chetan, Shin, Joo Heon, Lim, Michael, Park, Chul-Kee
Publié dans Acta Neuropathol Commun (2019)

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

par Belcaid, Zineb, Berrevoets, Cor, Choi, John, van Beelen, Edward, Stavrakaki, Eftychia, Pierson, Tessa, Kloezeman, Jenneke, Routkevitch, Denis, van der Kaaij, Mariëlle, van der Ploeg, Alicia, Mathios, Dimitrios, Sleijfer, Stefan, Dirven, Clemens, Lim, Michael, Debets, Reno, Lamfers, Martine L M
Publié dans Neurooncol Adv (2020)

IMPS-20 COMBINATION THERAPY WITH ANTI-PD-1, ANTI-TIM-3, AND FOCAL RADIATION RESULTS IN REGRESSION OF MURINE GLIOMAS

par Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Polanczyk, Magda, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric, Mathios, Dimitrios, Jackson, Christopher M., Olivi, Alessandro, Tran, Phuoc, Drake, Charles G., Tyler, Betty, Ye, Xiaobu, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publié dans Neuro Oncol (2015)

Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

par Mathios, Dimitrios, Kim, Jennifer E., Mangraviti, Antonella, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher M., Garzon-Muvdi, Tomas, Kim, Eileen, Theodros, Debebe, Polanczyk, Magdalena, Martin, Allison M., Suk, Ian, Ye, Xiaobu, Tyler, Betty, Bettegowda, Chetan, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publié dans Sci Transl Med (2016)

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

par Belcaid, Zineb, Phallen, Jillian A., Zeng, Jing, See, Alfred P., Mathios, Dimitrios, Gottschalk, Chelsea, Nicholas, Sarah, Kellett, Meghan, Ruzevick, Jacob, Jackson, Christopher, Albesiano, Emilia, Durham, Nicholas M., Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Wong, John W., Brem, Henry, Pardoll, Drew M., Drake, Charles G., Lim, Michael
Publié 2014

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

par Maxwell, Russell, Luksik, Andrew S., Garzon-Muvdi, Tomas, Hung, Alice L., Kim, Eileen S., Wu, Adela, Xia, Yuanxuan, Belcaid, Zineb, Gorelick, Noah, Choi, John, Theodros, Debebe, Jackson, Christopher M., Mathios, Dimitrios, Ye, Xiaobu, Tran, Phuoc T., Redmond, Kristin J., Brem, Henry, Pardoll, Drew M., Kleinberg, Lawrence R., Lim, Michael
Publié dans Oncoimmunology (2018)

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

par Harris-Bookman, Sarah, Mathios, Dimitrios, Martin, Allison M., Xia, Yuanxuan, Kim, Eileen, Xu, Haiying, Belcaid, Zineb, Polanczyk, Magdalena, Barberi, Theresa, Theodros, Debebe, Kim, Jennifer, Taube, Janis M., Burger, Peter C., Selby, Mark, Taitt, Corina, Korman, Alan, Ye, Xiaobu, Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Publié dans Int J Cancer (2018)

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

par Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Publié dans Proc Natl Acad Sci U S A (2017)

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

par Hung, Alice L., Maxwell, Russell, Theodros, Debebe, Belcaid, Zineb, Mathios, Dimitrios, Luksik, Andrew S., Kim, Eileen, Wu, Adela, Xia, Yuanxuan, Garzon-Muvdi, Tomas, Jackson, Christopher, Ye, Xiaobu, Tyler, Betty, Selby, Mark, Korman, Alan, Barnhart, Bryan, Park, Su-Myeong, Youn, Je-In, Chowdhury, Tamrin, Park, Chul-Kee, Brem, Henry, Pardoll, Drew M., Lim, Michael
Publié dans Oncoimmunology (2018)

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

par Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Publié dans Proc Natl Acad Sci U S A (2018)

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

par Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Publié dans J Immunother Cancer (2016)

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

par Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Publié dans J Immunother Cancer (2016)

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

par Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric W., Tam, Ada, Xu, Haiying, Mathios, Dimitrios, Jackson, Christopher M., Harris-Bookman, Sarah, Garzon-Muvdi, Tomas, Sheu, Mary, Martin, Allison M., Tyler, Betty M., Tran, Phuoc T., Ye, Xiaobu, Olivi, Alessandro, Taube, Janis M., Burger, Peter C., Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Publié dans Clin Cancer Res (2016)