Why is immunotherapy for glioblastoma “Lag”-ging

by Mathios, Dimitrios, Lim, Michael
Published in Oncotarget (2019)

New Prospects for Molecular Targets for Chordomas

by Ozair, Mohammad Zeeshan, Shah, Pavan, Mathios, Dimitrios, Lim, Michael, Moss, Nelson S.
Published in Neurosurg Clin N Am (2020)

Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement

by Eseonu, Chikezie I., Goodwin, C. Rory, Zhou, Xin, Theodros, Debebe, Bender, Matthew T., Mathios, Dimitrios, Bettegowda, Chetan, Lim, Michael
Published in J Neurosurg (2015)

IT-21 PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODE...

by Mathios, Dimitrios, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher, Nicholas, Sarah, Tyler, Betty, Pardoll, Drew, Brem, Henry, Lim, Michael
Published 2014

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

by Mathios, Dimitrios, Park, Chul-Kee, Marcus, Warren D., Alter, Sarah, Rhode, Peter R., Jeng, Emily K., Wong, Hing C., Pardoll, Drew M., Lim, Michael
Published in Int J Cancer (2015)

PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

by Mathios, Dimitrios, Ruzevick, Jacob, Jackson, Christopher M., Xu, Haiying, Shah, Sagar, Taube, Janis M., Burger, Peter C., McCarthy, Edward F., Quinones-Hinojosa, Alfredo, Pardoll, Drew M., Lim, Michael
Published in J Neurooncol (2014)

Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model

by Mathios, Dimitrios, Kim, Jennifer, Phallen, Jillian, Mangraviti, Antonella, Park, Chul-Kee, Theodros, Debebe, Jackson, Christopher, Garzon-Muvdi, Tomas, Kim, Eileen, Ye, Xiaobu, Tyler, Betty, Brem, Henry, Pardoll, Drew, Lim, Michael
Published in J Immunother Cancer (2015)

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

by Hwang, Taeyoung, Mathios, Dimitrios, McDonald, Kerrie L., Daris, Irene, Park, Sung-Hye, Burger, Peter C., Kim, Sojin, Dho, Yun-Sik, Carolyn, Hruban, Bettegowda, Chetan, Shin, Joo Heon, Lim, Michael, Park, Chul-Kee
Published in Acta Neuropathol Commun (2019)

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

by Belcaid, Zineb, Berrevoets, Cor, Choi, John, van Beelen, Edward, Stavrakaki, Eftychia, Pierson, Tessa, Kloezeman, Jenneke, Routkevitch, Denis, van der Kaaij, Mariëlle, van der Ploeg, Alicia, Mathios, Dimitrios, Sleijfer, Stefan, Dirven, Clemens, Lim, Michael, Debets, Reno, Lamfers, Martine L M
Published in Neurooncol Adv (2020)

IMPS-20 COMBINATION THERAPY WITH ANTI-PD-1, ANTI-TIM-3, AND FOCAL RADIATION RESULTS IN REGRESSION OF MURINE GLIOMAS

by Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Polanczyk, Magda, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric, Mathios, Dimitrios, Jackson, Christopher M., Olivi, Alessandro, Tran, Phuoc, Drake, Charles G., Tyler, Betty, Ye, Xiaobu, Brem, Henry, Pardoll, Drew M., Lim, Michael
Published in Neuro Oncol (2015)

Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

by Mathios, Dimitrios, Kim, Jennifer E., Mangraviti, Antonella, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher M., Garzon-Muvdi, Tomas, Kim, Eileen, Theodros, Debebe, Polanczyk, Magdalena, Martin, Allison M., Suk, Ian, Ye, Xiaobu, Tyler, Betty, Bettegowda, Chetan, Brem, Henry, Pardoll, Drew M., Lim, Michael
Published in Sci Transl Med (2016)

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

by Belcaid, Zineb, Phallen, Jillian A., Zeng, Jing, See, Alfred P., Mathios, Dimitrios, Gottschalk, Chelsea, Nicholas, Sarah, Kellett, Meghan, Ruzevick, Jacob, Jackson, Christopher, Albesiano, Emilia, Durham, Nicholas M., Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Wong, John W., Brem, Henry, Pardoll, Drew M., Drake, Charles G., Lim, Michael
Published 2014

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

by Maxwell, Russell, Luksik, Andrew S., Garzon-Muvdi, Tomas, Hung, Alice L., Kim, Eileen S., Wu, Adela, Xia, Yuanxuan, Belcaid, Zineb, Gorelick, Noah, Choi, John, Theodros, Debebe, Jackson, Christopher M., Mathios, Dimitrios, Ye, Xiaobu, Tran, Phuoc T., Redmond, Kristin J., Brem, Henry, Pardoll, Drew M., Kleinberg, Lawrence R., Lim, Michael
Published in Oncoimmunology (2018)

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

by Harris-Bookman, Sarah, Mathios, Dimitrios, Martin, Allison M., Xia, Yuanxuan, Kim, Eileen, Xu, Haiying, Belcaid, Zineb, Polanczyk, Magdalena, Barberi, Theresa, Theodros, Debebe, Kim, Jennifer, Taube, Janis M., Burger, Peter C., Selby, Mark, Taitt, Corina, Korman, Alan, Ye, Xiaobu, Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Published in Int J Cancer (2018)

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

by Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Published in Proc Natl Acad Sci U S A (2017)

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

by Hung, Alice L., Maxwell, Russell, Theodros, Debebe, Belcaid, Zineb, Mathios, Dimitrios, Luksik, Andrew S., Kim, Eileen, Wu, Adela, Xia, Yuanxuan, Garzon-Muvdi, Tomas, Jackson, Christopher, Ye, Xiaobu, Tyler, Betty, Selby, Mark, Korman, Alan, Barnhart, Bryan, Park, Su-Myeong, Youn, Je-In, Chowdhury, Tamrin, Park, Chul-Kee, Brem, Henry, Pardoll, Drew M., Lim, Michael
Published in Oncoimmunology (2018)

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic

by Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.
Published in Proc Natl Acad Sci U S A (2018)

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

by Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Published in J Immunother Cancer (2016)

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

by Patel, Mira A., Kim, Jennifer E., Theodros, Debebe, Tam, Ada, Velarde, Esteban, Kochel, Christina M., Francica, Brian, Nirschl, Thomas R., Ghasemzadeh, Ali, Mathios, Dimitrios, Harris-Bookman, Sarah, Jackson, Christopher C., Jackson, Christina, Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Coric, Vladimir, Selby, Mark, Brem, Henry, Drake, Charles G., Pardoll, Drew M., Lim, Michael
Published in J Immunother Cancer (2016)

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

by Kim, Jennifer E., Patel, Mira A., Mangraviti, Antonella, Kim, Eileen S., Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric W., Tam, Ada, Xu, Haiying, Mathios, Dimitrios, Jackson, Christopher M., Harris-Bookman, Sarah, Garzon-Muvdi, Tomas, Sheu, Mary, Martin, Allison M., Tyler, Betty M., Tran, Phuoc T., Ye, Xiaobu, Olivi, Alessandro, Taube, Janis M., Burger, Peter C., Drake, Charles G., Brem, Henry, Pardoll, Drew M., Lim, Michael
Published in Clin Cancer Res (2016)