Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

The immunosuppressive effects of chemotherapy present a challenge for designing effective cancer immunotherapy strategies. We hypothesized that although systemic chemotherapy (SC) exhibits negative immunologic effects, local chemotherapy (LC) can potentiate an antitumor immune response. We show that...

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Publicado en:Sci Transl Med
Main Authors: Mathios, Dimitrios, Kim, Jennifer E., Mangraviti, Antonella, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher M., Garzon-Muvdi, Tomas, Kim, Eileen, Theodros, Debebe, Polanczyk, Magdalena, Martin, Allison M., Suk, Ian, Ye, Xiaobu, Tyler, Betty, Bettegowda, Chetan, Brem, Henry, Pardoll, Drew M., Lim, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724383/
https://ncbi.nlm.nih.gov/pubmed/28003545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag2942
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