IT-16 COMBINATION TREATMENT WITH DELTA24-RGD AND TEMOZOLOMIDE IMPROVES SURVIVAL AND AFFECTS INTRATUMORAL IMMUNE CELL SUBSETS IN A MURINE MALIGNANT GLIOMA MODEL

Por Kleijn, Anne, van den Bossche, Wouter, Haefner, Eric, Belcaid, Zineb, Kloezeman, Jenneke, Dirven, Clemens, Lamfers, Martine
Publicado em 2014

The In Vivo Therapeutic Efficacy of the Oncolytic Adenovirus Delta24-RGD Is Mediated by Tumor-Specific Immunity

Por Kleijn, Anne, Kloezeman, Jenneke, Treffers-Westerlaken, Elike, Fulci, Giulia, Leenstra, Sieger, Dirven, Clemens, Debets, Reno, Lamfers, Martine
Publicado em 2014

The therapeutic efficacy of the oncolytic virus Delta24-RGD in a murine glioma model depends primarily on antitumor immunity

Por Kleijn, Anne, Kloezeman, Jenneke, Treffers-Westerlaken, Elike, Fulci, Giulia, Leenstra, Sieger, Dirven, Clemens, Debets, Reno, Lamfers, Martine
Publicado no Oncoimmunology (2014)

ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells

Por Balvers, Rutger K, Lamfers, Martine LM, Kloezeman, Jenneke J, Kleijn, Anne, Berghauser Pont, Lotte ME, Dirven, Clemens MF, Leenstra, Sieger
Publicado no J Transl Med (2015)

Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix–associated gene modules

Por Balvers, Rutger K., Kleijn, Anne, Kloezeman, Jenneke J., French, Pim J., Kremer, Andreas, van den Bent, Martin J., Dirven, Clemens M. F., Leenstra, Sieger, Lamfers, Martine L. M.
Publicado em 2013

Locally-Delivered T-Cell-Derived Cellular Vehicles Efficiently Track and Deliver Adenovirus Delta24-RGD to Infiltrating Glioma

Por Balvers, Rutger K., Belcaid, Zineb, van den Hengel, Sanne K., Kloezeman, Jenneke, de Vrij, Jeroen, Wakimoto, Hiroaki, Hoeben, Rob C., Debets, Reno, Leenstra, Sieger, Dirven, Clemens, Lamfers, Martine L.M.
Publicado em 2014

The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells

Por Berghauser Pont, Lotte M.E., Kleijn, Anne, Kloezeman, Jenneke J., van den Bossche, Wouter, Kaufmann, Johanna K., de Vrij, Jeroen, Leenstra, Sieger, Dirven, Clemens M.F., Lamfers, Martine L.M.
Publicado no PLoS One (2015)

The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells

Por Berghauser Pont, Lotte M.E., Spoor, Jochem K.H., Venkatesan, Subramanian, Swagemakers, Sigrid, Kloezeman, Jenneke J., Dirven, Clemens M.F., van der Spek, Peter J., Lamfers, Martine L.M., Leenstra, Sieger
Publicado no Genes Cancer (2014)

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8(+)T Cell Anti-tumor Activity

Por Kleijn, Anne, van den Bossche, Wouter, Haefner, Erik S., Belcaid, Zineb, Burghoorn-Maas, Chantal, Kloezeman, Jenneke J., Pas, Suzan D., Leenstra, Sieger, Debets, Reno, de Vrij, Jeroen, Dirven, Clemens M.F., Lamfers, Martine L.M.
Publicado no Mol Ther Oncolytics (2017)

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

Por Belcaid, Zineb, Berrevoets, Cor, Choi, John, van Beelen, Edward, Stavrakaki, Eftychia, Pierson, Tessa, Kloezeman, Jenneke, Routkevitch, Denis, van der Kaaij, Mariëlle, van der Ploeg, Alicia, Mathios, Dimitrios, Sleijfer, Stefan, Dirven, Clemens, Lim, Michael, Debets, Reno, Lamfers, Martine L M
Publicado no Neurooncol Adv (2020)

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mT...

Por Venkatesan, Subramanian, Hoogstraat, Marlous, Caljouw, Ester, Pierson, Tessa, Spoor, Jochem K.H., Zeneyedpour, Lona, Dubbink, Hendrikus J., Dekker, Lennard J., van der Kaaij, Mariëlle, Kloezeman, Jenneke, Berghauser Pont, Lotte M.E., Besselink, Nicolle J.M., Luider, Theo M., Joore, Jos, Martens, John W., Lamfers, Martine L.M., Sleijfer, Stefan, Leenstra, Sieger
Publicado no Oncotarget (2016)

DNA methylation and somatic mutations converge on cell cycle and define similar evolutionary histories in brain tumors

Por Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Hamilton, Emily G., Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael J., Idbaih, Ahmed, Alentorn, Agusti, Kloezeman, Jenneke J., Lamfers, Martine L. M., Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Chang, Susan M., Song, Jun S., Costello, Joseph F.
Publicado no Cancer Cell (2015)

Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

Por van Thuijl, Hinke F., Mazor, Tali, Johnson, Brett E., Fouse, Shaun D., Aihara, Koki, Hong, Chibo, Malmström, Annika, Hallbeck, Martin, Heimans, Jan J., Kloezeman, Jenneke J., Stenmark-Askmalm, Marie, Lamfers, Martine L.M., Saito, Nobuhito, Aburatani, Hiroyuki, Mukasa, Akitake, Berger, Mitchell S., Söderkvist, Peter, Taylor, Barry S., Molinaro, Annette M., Wesseling, Pieter, Reijneveld, Jaap C., Chang, Susan M., Ylstra, Bauke, Costello, Joseph F.
Publicado no Acta Neuropathol (2015)