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ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells
BACKGROUND: The current standard of care for Glioblastoma Multiforme (GBM) consists of fractionated focal irradiation with concomitant temozolomide (TMZ) chemotherapy. A promising strategy to increase the efficacy of TMZ is through interference with the DNA damage repair machinery, by poly(ADP-ribos...
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| Veröffentlicht in: | J Transl Med |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359449/ https://ncbi.nlm.nih.gov/pubmed/25886061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0427-y |
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