ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells

BACKGROUND: The current standard of care for Glioblastoma Multiforme (GBM) consists of fractionated focal irradiation with concomitant temozolomide (TMZ) chemotherapy. A promising strategy to increase the efficacy of TMZ is through interference with the DNA damage repair machinery, by poly(ADP-ribos...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Balvers, Rutger K, Lamfers, Martine LM, Kloezeman, Jenneke J, Kleijn, Anne, Berghauser Pont, Lotte ME, Dirven, Clemens MF, Leenstra, Sieger
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359449/
https://ncbi.nlm.nih.gov/pubmed/25886061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0427-y
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