Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined. DNA hypermethylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is associated with an improve...

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Vydáno v:Acta Neuropathol
Hlavní autoři: van Thuijl, Hinke F., Mazor, Tali, Johnson, Brett E., Fouse, Shaun D., Aihara, Koki, Hong, Chibo, Malmström, Annika, Hallbeck, Martin, Heimans, Jan J., Kloezeman, Jenneke J., Stenmark-Askmalm, Marie, Lamfers, Martine L.M., Saito, Nobuhito, Aburatani, Hiroyuki, Mukasa, Akitake, Berger, Mitchell S., Söderkvist, Peter, Taylor, Barry S., Molinaro, Annette M., Wesseling, Pieter, Reijneveld, Jaap C., Chang, Susan M., Ylstra, Bauke, Costello, Joseph F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482618/
https://ncbi.nlm.nih.gov/pubmed/25724300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1403-6
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