IT-16 COMBINATION TREATMENT WITH DELTA24-RGD AND TEMOZOLOMIDE IMPROVES SURVIVAL AND AFFECTS INTRATUMORAL IMMUNE CELL SUBSETS IN A MURINE MALIGNANT GLIOMA MODEL

INTRODUCTION: The oncolytic adenovirus Delta24-RGD specifically lyses tumor cells and is currently tested in clinical phase I/II trials for recurrent glioma. We recently showed that the efficacy of Delta24-RGD is mainly dependent on an induced anti-tumor immune response. As known, TMZ has pronounced...

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Main Authors: Kleijn, Anne, van den Bossche, Wouter, Haefner, Eric, Belcaid, Zineb, Kloezeman, Jenneke, Dirven, Clemens, Lamfers, Martine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218232/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou258.14
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