Evaluation of a novel CD20-targeted IL-15 immunotherapeutic with potent activity against B cell lymphoma

Por Liu, Bai, Kong, Lin, Marcus, Warren D, Chen, Xiaoyue, Han, Kaiping, Rhode, Peter R, Wong, Hing C
Publicado no J Immunother Cancer (2014)

Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syng...

Por Chen, Xiaoyue, Liu, Bai, Han, Kaiping, Kong, Lin, Noel, Terra, Jeng, Emily K, Alter, Sarah, Rubinstein, Mark, Rhode, Peter R, Wong, Hing C
Publicado no J Immunother Cancer (2015)

Novel Human Interleukin-15 Agonists

Por Zhu, Xiaoyun, Marcus, Warren D., Xu, Wenxin, Lee, Hyung-Il, Han, Kaiping, Egan, Jack O., Yovandich, Jason L., Rhode, Peter R., Wong, Hing C.
Publicado em 2009

Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells

Por Xu, Wenxin, Egan, Jack O, Liu, Bai, Chen, Xiaoyue, You, Lijing, Han, Kaiping, Marcus, Warren D, Kong, Lin, Jones, Monica, Jeng, Emily K, Rhode, Peter R, Wong, Hing C
Publicado no J Immunother Cancer (2014)

Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor α/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma

Por Xu, Wenxin, Jones, Monica, Liu, Bai, Zhu, Xiaoyun, Johnson, C. Bryce, Edwards, Ana C., Kong, Lin, Jeng, Emily K., Han, Kaiping, Marcus, Warren D., Rubinstein, Mark P., Rhode, Peter R., Wong, Hing C.
Publicado em 2013

A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses

Por Liu, Bai, Kong, Lin, Han, Kaiping, Hong, Hao, Marcus, Warren D., Chen, Xiaoyue, Jeng, Emily K., Alter, Sarah, Zhu, Xiaoyun, Rubinstein, Mark P., Shi, Sixiang, Rhode, Peter R., Cai, Weibo, Wong, Hing C.
Publicado no J Biol Chem (2016)

Comparison of the super agonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models

Por Rhode, Peter R., Egan, Jack O., Xu, Wenxin, Hong, Hao, Webb, Gabriela M., Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C., Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B., Jeng, Emily K., Cai, Weibo, Wong, Hing C.
Publicado no Cancer Immunol Res (2015)

The IL-15-based ALT-803 complex enhances FcγRIIIa-triggered NK cell responses and in vivo clearance of B cell lymphomas

Por Rosario, Maximillian, Bai, Liu, Kong, Lin, Collins, Lynne I., Schneider, Stephanie E., Chen, Xiaoyue, Han, Kaiping, Jeng, Emily K., Rhode, Peter R., Leong, Jeffrey W., Schappe, Timothy, Jewell, Brea A., Keppel, Catherine R., Shah, Keval, Hess, Brian, Romee, Rizwan, Piwnica-Worms, David R., Cashen, Amanda F., Bartlett, Nancy L., Wong, Hing C., Fehniger, Todd A.
Publicado no Clin Cancer Res (2015)