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Comparison of the super agonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models

Interleukin-15 (IL-15), a potent stimulant of CD8(+) T and NK cells, is a promising cancer immunotherapeutic. ALT-803 is a complex of an IL-15 superagonist mutant and a dimeric IL-15 receptor αSu/Fc fusion protein that was found to exhibit enhanced biologic activity in vivo with a substantially long...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Immunol Res
मुख्य लेखकों: Rhode, Peter R., Egan, Jack O., Xu, Wenxin, Hong, Hao, Webb, Gabriela M., Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C., Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B., Jeng, Emily K., Cai, Weibo, Wong, Hing C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703482/
https://ncbi.nlm.nih.gov/pubmed/26511282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0093-T
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