Enhanced efficacy of IL-15-based ALT-803 superagonist complex in combination with immune checkpoint inhibitors in hematologic and metastatic mouse tumor models

Antzeko izenburuak

• Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice
  nork: Xu, Wenxin, et al.
  Argitaratua: (2015)
• CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma
  nork: Margolin, Kim, et al.
  Argitaratua: (2014)
• IL15N72D superagonist/IL15Rα-Fc fusion complex (ALT-803) exhibits anti-metastatic activity in murine breast tumor model
  nork: Kim, Peter S, et al.
  Argitaratua: (2015)
• The IL-15 superagonist ALT-803 enhances anti-CD20 antibody-directed NK cell ADCC and in vivo clearance of B cell lymphomas
  nork: Rosario, Maximillian, et al.
  Argitaratua: (2014)
• Combinatorial therapy with an IL-15 superagonist (ALT-803) and anti-PD-L1 mAb augment T cell mediated anti-tumor immunity in mice
  nork: Johnson, Christopher B, et al.
  Argitaratua: (2014)