Comparison of the super agonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models

Interleukin-15 (IL-15), a potent stimulant of CD8(+) T and NK cells, is a promising cancer immunotherapeutic. ALT-803 is a complex of an IL-15 superagonist mutant and a dimeric IL-15 receptor αSu/Fc fusion protein that was found to exhibit enhanced biologic activity in vivo with a substantially long...

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Publié dans:Cancer Immunol Res
Auteurs principaux: Rhode, Peter R., Egan, Jack O., Xu, Wenxin, Hong, Hao, Webb, Gabriela M., Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C., Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B., Jeng, Emily K., Cai, Weibo, Wong, Hing C.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703482/
https://ncbi.nlm.nih.gov/pubmed/26511282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0093-T
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