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Comparison of the super agonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models

Interleukin-15 (IL-15), a potent stimulant of CD8(+) T and NK cells, is a promising cancer immunotherapeutic. ALT-803 is a complex of an IL-15 superagonist mutant and a dimeric IL-15 receptor αSu/Fc fusion protein that was found to exhibit enhanced biologic activity in vivo with a substantially long...

詳細記述

保存先:
書誌詳細
出版年:Cancer Immunol Res
主要な著者: Rhode, Peter R., Egan, Jack O., Xu, Wenxin, Hong, Hao, Webb, Gabriela M., Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C., Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B., Jeng, Emily K., Cai, Weibo, Wong, Hing C.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703482/
https://ncbi.nlm.nih.gov/pubmed/26511282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0093-T
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