Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules

Human interleukin-15 (hIL-15) and its receptor α (hIL-15Rα) are co-expressed in antigen presenting cells allowing trans-presentation of the cytokine to immune effector cells. We exploited the high-affinity interactions between hIL-15 and the extracellular hIL-15Rα sushi domain (hIL-15RαSu) to create...

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Библиографические подробности
Главные авторы: Wong, Richard L., Liu, Bai, Zhu, Xiaoyun, You, Lijing, Kong, Lin, Han, Kai-Ping, Lee, Hyung-il, Chavaillaz, Pierre-Andre, Jin, Moonsoo, Wang, Yi, Rhode, Peter R., Wong, Hing C.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049345/
https://ncbi.nlm.nih.gov/pubmed/21177283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq116
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