Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

Por Ragupathi, Govind, Gardner, Jeffrey R, Livingston, Philip O, Gin, David Y
Publicado em 2011

Accelerated Tumor Growth Mediated by Sub-lytic Levels of Antibody-Induced Complement Activation is Associated with Activation of the PI3K/AKT Survival Pathway

Por Wu, Xiaohong, Ragupathi, Govind, Panageas, Katherine, Hong, Feng, Livingston, Philip O.
Publicado em 2013

Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine

Por Deng, Kai, Adams, Michelle M., Damani, Payal, Livingston, Philip O., Ragupathi, Govind, Gin, David Y.
Publicado em 2008

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

Por Zhu, Jianglong, Wan, Qian, Ragupathi, Govind, George, Constantine M., Livingston, Philip O., Danishefsky, Samuel J.
Publicado em 2009

Synthesis of sialyl Lewis(a) (sLe(a), CA19-9) and construction of an immunogenic sLe(a) vaccine

Por Ragupathi, Govind, Damani, Payal, Srivastava, Geeta, Srivastava, Om, Sucheck, Steven J., Ichikawa, Yoshi, Livingston, Philip O.
Publicado em 2009

Human Monoclonal Antibodies to Sialyl-Lewis (a) (CA19.9) with Potent CDC, ADCC and Anti-Tumor Activity

Por Sawada, Ritsuko, Sun, Shu-Man, Wu, Xiaohong, Hong, Feng, Ragupathi, Govind, Livingston, Philip O., Scholz, Wolfgang W.
Publicado em 2011

Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand

Por Park, Jun-Eui, Wu, Dianna Y, Prendes, Maria, Lu, Sharon X, Ragupathi, Govind, Schrantz, Nicolas, Chapman, Paul B
Publicado em 2008

Preclinical Evaluation of the Synthetic Adjuvant SQS-21 and its Constituent Isomeric Saponins

Por Ragupathi, Govind, Damani, Payal, Deng, Kai, Adams, Michelle M., Hang, Jianfeng, George, Constantine, Livingston, Philip O., Gin, David Y.
Publicado em 2010

Impact of minimal tumor burden on antibody response to vaccination

Por Kim, Soo-Kie, Wu, Xiaohong, Ragupathi, Govind, Gathuru, John, Koide, Fusataka, Cheung, Nai-Kong, Panageas, Katherine, Livingston, Philip O.
Publicado em 2011

Design and Synthesis of Potent Quillaja Saponin Vaccine Adjuvants

Por Adams, Michelle M., Damani, Payal, Perl, Nicholas R., Won, Annie, Hong, Feng, Livingston, Philip O., Ragupathi, Govind, Gin, David Y.
Publicado em 2010

Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Por Walkowicz, William E., Fernández-Tejada, Alberto, George, Constantine, Corzana, Francisco, Jiménez-Barbero, Jesús, Ragupathi, Govind, Tan, Derek S., Gin, David Y.
Publicado no Chem Sci (2016)

Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol

Por Fernández-Tejada, Alberto, Chea, Eric K., George, Constantine, Gardner, Jeffrey R., Livingston, Philip O., Ragupathi, Govind, Tan, Derek S., Gin, David Y.
Publicado no Bioorg Med Chem (2014)

Evaluation of Widely Consumed Botanicals as Immunological Adjuvants

Por Ragupathi, Govind, Hood, Chandra, Yeung, K. Simon, Vickers, Andrew, Hood, Chandra, Deng, Gary, Cheung, Nai-Kong, Vickers, Andrew, Cassileth, Barrie, Livingston, Philip
Publicado em 2008

Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes

Por Chea, Eric K., Fernández-Tejada, Alberto, Damani, Payal, Adams, Michelle M., Gardner, Jeffrey R., Livingston, Philip O., Ragupathi, Govind, Gin, David Y.
Publicado em 2012

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

Por Chang, David H., Deng, Haiteng, Matthews, Phillip, Krasovsky, Joseph, Ragupathi, Govind, Spisek, Radek, Mazumder, Amitabha, Vesole, David H., Jagannath, Sundar, Dhodapkar, Madhav V.
Publicado em 2008

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

Por Zhu, Jianglong, Wan, Qian, Lee, Dongjoo, Yang, Guangbin, Spassova, Maria K., Ouerfelli, Ouathek, Ragupathi, Govind, Damani, Payal, Livingston, Philip O., Danishefsky, Samuel J.
Publicado em 2009

The Known Immunologically Active Components of Astragalus Account for Only a Small Proportion of the Immunological Adjuvant Activity When Combined with Conjugate Vaccines

Por Hong, Feng, Xiao, Weilie, Ragupathi, Govind, Lau, Clara B. S., Leung, Ping Chung, Yeung, K. Simon, George, Constantine, Cassileth, Barrie, Kennelly, Edward, Livingston, Philip O.
Publicado em 2010

Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal aga...

Por Krug, Lee M., Ragupathi, Govind, Hood, Chandra, George, Constantine, Hong, Feng, Shen, Ronglai, Abrey, Lauren, Jennings, Harold J., Kris, Mark G., Livingston, Philip O.
Publicado em 2011

HLA-DR peptide occupancy can be regulated with a wide variety of small molecules

Por Blazekovic, Francesca, Odukoya, Dana, Butler, Shanitra N., Mauro, James A., Ramsamooj, Michael, Puleo, Erika, Szekeres, Karoly, Dana, Dibyendu, Kumar, Sanjai, Ragupathi, Govind, Blanck, George
Publicado no Hum Vaccin Immunother (2015)

Deciphering Structural Elements of Mucin Glycoprotein Recognition

Por Borgert, Andrew, Heimburg-Molinaro, Jamie, Song, Xuezheng, Lasanajak, Yi, Ju, Tongzhong, Liu, Mian, Thompson, Pamela, Ragupathi, Govind, Barany, George, Smith, David F., Cummings, Richard D., Live, David
Publicado em 2012