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Accelerated Tumor Growth Mediated by Sub-lytic Levels of Antibody-Induced Complement Activation is Associated with Activation of the PI3K/AKT Survival Pathway

PURPOSE: We addressed the possibility that low levels of tumor cell bound antibodies targeting gangliosides might accelerate tumor growth. EXPERIMENTAL DESIGN: To test this hypothesis, we treated mice with a range of mAb doses against GM2, GD2, GD3 and CD20 after challenge with tumors expressing the...

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Bibliografische gegevens
Hoofdauteurs: Wu, Xiaohong, Ragupathi, Govind, Panageas, Katherine, Hong, Feng, Livingston, Philip O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769223/
https://ncbi.nlm.nih.gov/pubmed/23833306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0088
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