PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabiliz...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Lee, Min-Sik, Jeong, Man-Hyung, Lee, Hyun-Woo, Han, Hyun-Ji, Ko, Aram, Hewitt, Stephen M., Kim, Jae-Hoon, Chun, Kyung-Hee, Chung, Joon-Yong, Lee, Cheolju, Cho, Hanbyoul, Song, Jaewhan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518267/
https://ncbi.nlm.nih.gov/pubmed/26183061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8769
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы