RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

The PTEN tumor suppressor is a lipid phosphatase that has a central role in regulating the phosphatidylinositol-3-kinase (PI3K) signal transduction cascade. Nevertheless, the mechanism by which the PTEN activity is regulated in cells needs further elucidation. Although previous studies have shown th...

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Autori principali: Lee, James T, Shan, Jing, Zhong, Jiayun, Li, Muyang, Zhou, Brenda, Zhou, Amanda, Parsons, Ramon, Gu, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616435/
https://ncbi.nlm.nih.gov/pubmed/23419514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.27
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