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RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
The PTEN tumor suppressor is a lipid phosphatase that has a central role in regulating the phosphatidylinositol-3-kinase (PI3K) signal transduction cascade. Nevertheless, the mechanism by which the PTEN activity is regulated in cells needs further elucidation. Although previous studies have shown th...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616435/ https://ncbi.nlm.nih.gov/pubmed/23419514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.27 |
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