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Mechanistic Studies of MDM2-mediated Ubiquitination in p53 Regulation

As a central regulator for cell cycle arrest, apoptosis, and cellular senescence, p53 requires multiple layers of regulatory control to ensure correct temporal and spatial functions. It is well accepted that Mdm2-mediated ubiquitination plays a crucial role in p53 regulation. In addition to proteaso...

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Detalhes bibliográficos
Main Authors: Brooks, Christopher L., Li, Muyang, Gu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737768/
https://ncbi.nlm.nih.gov/pubmed/17500067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700961200
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