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Discovery of the PTEN Tumor Suppressor and Its Connection to the PI3K and AKT Oncogenes

PTEN (phosphatase and tensin homolog on chromosome 10) was discovered over 20 years ago in 1997 and linked to the phosphatidylinositol 3-kinase (PI3K) and AKT oncogenes the following year. The discovery of PTEN emerged from the linked concepts of oncogenes and tumor suppressor genes that cause and p...

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Bibliografiske detaljer
Udgivet i:Cold Spring Harb Perspect Med
Hovedforfatter: Parsons, Ramon
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397838/
https://ncbi.nlm.nih.gov/pubmed/31932465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a036129
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