Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

by Che, Li, Paliogiannis, Panagiotis, Cigliano, Antonio, Pilo, Maria G., Chen, Xin, Calvisi, Diego F.
Published in Front Oncol (2019)

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

by Li, Lei, Wang, Chunmei, Calvisi, Diego F., Evert, Matthias, Pilo, Maria G., Jiang, Lijie, Yuneva, Mariia, Chen, Xin
Published 2013

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

by Jia, Jiaoyuan, Qiao, Yu, Pilo, Maria G., Cigliano, Antonio, Liu, Xianqiong, Shao, Zixuan, Calvisi, Diego F., Chen, Xin
Published in PLoS One (2017)

PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men

by Ribback, Silvia, Cigliano, Antonio, Kroeger, Nils, Pilo, Maria G., Terracciano, Luigi, Burchardt, Martin, Bannasch, Peter, Calvisi, Diego F., Dombrowski, Frank
Published in Oncotarget (2015)

Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma

by Che, Li, Pilo, Maria G., Cigliano, Antonio, Latte, Gavinella, Simile, Maria M., Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Published in Cell Cycle (2017)

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

by Xu, Zhong, Hu, Junjie, Cao, Hui, Pilo, Maria G, Cigliano, Antonio, Shao, Zixuan, Xu, Meng, Ribback, Silvia, Dombrowski, Frank, Calvisi, Diego F, Chen, Xin
Published in Exp Mol Med (2018)

Functional role of SGK3 in PI3K/Pten driven liver tumor development

by Cao, Hui, Xu, Zhong, Wang, Jingxiao, Cigliano, Antonio, Pilo, Maria G., Ribback, Silvia, Zhang, Shu, Qiao, Yu, Che, Li, Pascale, Rosa M., Calvisi, Diego F., Chen, Xin
Published in BMC Cancer (2019)

The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models

by Ribback, Silvia, Sailer, Verena, Böhning, Enrico, Günther, Julia, Merz, Jaqueline, Steinmüller, Frauke, Utpatel, Kirsten, Cigliano, Antonio, Peters, Kristin, Pilo, Maria G., Evert, Matthias, Calvisi, Diego F., Dombrowski, Frank
Published in Int J Mol Sci (2016)

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

by Hu, Junjie, Che, Li, Li, Lei, Pilo, Maria G., Cigliano, Antonio, Ribback, Silvia, Li, Xiaolei, Latte, Gavinella, Mela, Marta, Evert, Matthias, Dombrowski, Frank, Zheng, Guohua, Chen, Xin, Calvisi, Diego F.
Published in Sci Rep (2016)

Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma

by Ribback, Silvia, Che, Li, Pilo, Maria G., Cigliano, Antonio, Latte, Gavinella, Pes, Giovanni M., Porcu, Alberto, Pascale, Rosa M., Li, Lei, Qiao, Yu, Dombrowski, Frank, Chen, Xin, Calvisi, Diego F.
Published in Cell Cycle (2018)

4EBP1/eIF4E and p70S6K/RPS6 Axes Play Critical and Distinct Roles in Hepatocarcinogenesis Driven by AKT and N-Ras Protooncogenes

by Wang, Chunmei, Cigliano, Antonio, Jiang, Lijie, Li, Xiaolei, Fan, Biao, Pilo, Maria G., Liu, Yan, Gui, Bing, Sini, Marcella, Smith, Jeffrey W., Dombrowski, Frank, Calvisi, Diego F., Evert, Matthias, Chen, Xin
Published in Hepatology (2014)

Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumor formation in mice via AKT2/mTORC1 cascade

by Wang, Chunmei, Che, Li, Hu, Junjie, Zhang, Shanshan, Jiang, Lijie, Latte, Gavinella, Demartis, Maria I., Tao, Junyan, Gui, Bing, Pilo, Maria G., Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Calvisi, Diego F., Chen, Xin
Published in Liver Int (2016)

Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells

by Cao, Dan, Song, Xinhua, Che, Li, Li, Xiaolei, Pilo, Maria G., Vidili, Gianpaolo, Porcu, Alberto, Solinas, Antonio, Cigliano, Antonio, Pes, Giovanni M., Ribback, Silvia, Dombrowski, Frank, Chen, Xin, Li, Lei, Calvisi, Diego F.
Published in Liver Int (2016)

Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice

by Cigliano, Antonio, Wang, Chunmei, Pilo, Maria G., Szydlowska, Marta, Brozzetti, Stefania, Latte, Gavinella, Pes, Giovanni M., Pascale, Rosa M., Seddaiu, Maria A., Vidili, Gianpaolo, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Published in Oncotarget (2017)

Differential Requirement for de novo Lipogenesis in Cholangiocarcinoma and Hepatocellular Carcinoma of Mice and Humans

by Li, Lei, Che, Li, Tharp, Kevin M., Park, Hyo-Min, Pilo, Maria G., Cao, Dan, Cigliano, Antonio, Latte, Gavinella, Xu, Zhong, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Gores, Gregory J., Stahl, Andreas, Calvisi, Diego F., Chen, Xin
Published in Hepatology (2016)

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis

by Cigliano, Antonio, Pilo, Maria G., Li, Lei, Latte, Gavinella, Szydlowska, Marta, Simile, Maria M., Paliogiannis, Panagiotis, Che, Li, Pes, Giovanni M., Palmieri, Giuseppe, Sini, Maria C., Cossu, Antonio, Porcu, Alberto, Vidili, Gianpaolo, Seddaiu, Maria A., Pascale, Rosa M., Ribback, Silvia, Dombrowski, Frank, Chen, Xin, Calvisi, Diego F.
Published in Oncotarget (2017)

Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma

by Song, Xinhua, Liu, Xianqiong, Wang, Haichuan, Wang, Jingxiao, Qiao, Yu, Cigliano, Antonio, Utpatel, Kirsten, Ribback, Silvia, Pilo, Maria G., Serra, Marina, Gordan, John D., Che, Li, Zhang, Shanshan, Cossu, Antonio, Porcu, Alberto, Pascale, Rosa M., Dombrowski, Frank, Hu, Hongbo, Calvisi, Diego F., Evert, Matthias, Chen, Xin
Published in Clin Cancer Res (2018)

A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis

by Liu, Pin, Ge, Mengmeng, Hu, Junjie, Li, Xiaolei, Che, Li, Sun, Kun, Cheng, Lili, Huang, Yuedong, Pilo, Maria G., Cigliano, Antonio, Pes, Giovanni M., Pascale, Rosa M., Brozzetti, Stefania, Vidili, Gianpaolo, Porcu, Alberto, Cossu, Antonio, Palmieri, Giuseppe, Sini, Maria C., Ribback, Silvia, Dombrowski, Frank, Tao, Junyan, Calvisi, Diego F., Chen, Ligong, Chen, Xin
Published in Hepatology (2017)

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma induced in mice by AKT and Yap co-expression

by Zhang, Shanshan, Song, Xinhua, Cao, Dan, Xu, Zhong, Fan, Biao, Che, Li, Hu, Junjie, Chen, Bin, Dong, Mingjie, Pilo, Maria G., Cigliano, Antonio, Evert, Katja, Ribback, Silvia, Dombrowski, Frank, Pascale, Rosa M., Cossu, Antonio, Vidili, Gianpaolo, Porcu, Alberto, Simile, Maria M., Pes, Giovanni M., Giannelli, Gianluigi, Gordan, John, Wei, Lixin, Evert, Matthias, Cong, Wenming, Calvisi, Diego F., Chen, Xin
Published in J Hepatol (2017)

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

by Che, Li, Chi, Wenna, Qiao, Yu, Zhang, Jie, Song, Xinhua, Liu, Ye, Li, Lei, Jia, Jiaoyuan, Pilo, Maria G, Wang, Jingxiao, Cigliano, Antonio, Ma, Zhilong, Kuang, Wenhua, Tang, Zefang, Zhang, Zemin, Shui, Guanghou, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Pascale, Rosa Maria, Cossu, Carla, Pes, Giovanni Mario, Osborne, Timothy F, Calvisi, Diego F, Chen, Xin, Chen, Ligong
Published in Gut (2020)