Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumor formation in mice via AKT2/mTORC1 cascade

BACKGROUND & AIMS: Activating mutations of PIK3CA occur in various tumor types, including human hepatocellular carcinoma. The mechanisms whereby PIK3CA contributes to hepatocarcinogenesis remain poorly understood. METHODS: PIK3CA mutants H1047R or E545K were hydrodynamically transfected, either...

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Detalhes bibliográficos
Publicado no:Liver Int
Main Authors: Wang, Chunmei, Che, Li, Hu, Junjie, Zhang, Shanshan, Jiang, Lijie, Latte, Gavinella, Demartis, Maria I., Tao, Junyan, Gui, Bing, Pilo, Maria G., Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Calvisi, Diego F., Chen, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929046/
https://ncbi.nlm.nih.gov/pubmed/26716908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.13055
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