Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 and mTORC2. While mTORC1 has been e...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Xu, Zhong, Hu, Junjie, Cao, Hui, Pilo, Maria G, Cigliano, Antonio, Shao, Zixuan, Xu, Meng, Ribback, Silvia, Dombrowski, Frank, Calvisi, Diego F, Chen, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992985/
https://ncbi.nlm.nih.gov/pubmed/29303510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.158
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