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Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 and mTORC2. While mTORC1 has been e...
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| Publié dans: | Exp Mol Med |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992985/ https://ncbi.nlm.nih.gov/pubmed/29303510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.158 |
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