Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma induced in mice by AKT and Yap co-expression

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second-generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. METHODS: We established a novel ICC mouse model via hydrodynamic transfection of activate...

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Bibliografiset tiedot
Julkaisussa:J Hepatol
Päätekijät: Zhang, Shanshan, Song, Xinhua, Cao, Dan, Xu, Zhong, Fan, Biao, Che, Li, Hu, Junjie, Chen, Bin, Dong, Mingjie, Pilo, Maria G., Cigliano, Antonio, Evert, Katja, Ribback, Silvia, Dombrowski, Frank, Pascale, Rosa M., Cossu, Antonio, Vidili, Gianpaolo, Porcu, Alberto, Simile, Maria M., Pes, Giovanni M., Giannelli, Gianluigi, Gordan, John, Wei, Lixin, Evert, Matthias, Cong, Wenming, Calvisi, Diego F., Chen, Xin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696057/
https://ncbi.nlm.nih.gov/pubmed/28733220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2017.07.006
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