4EBP1/eIF4E and p70S6K/RPS6 Axes Play Critical and Distinct Roles in Hepatocarcinogenesis Driven by AKT and N-Ras Protooncogenes

Concomitant expression of activated forms of AKT and Ras in the mouse liver (AKT/Ras) leads to rapid tumor development via strong activation of the mTORC1 pathway. mTORC1 functions via regulating p70S6K/RPS6 and 4EBP1/eIF4E cascades. How these cascades contribute to hepatocarcinogenesis remains unkn...

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Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Wang, Chunmei, Cigliano, Antonio, Jiang, Lijie, Li, Xiaolei, Fan, Biao, Pilo, Maria G., Liu, Yan, Gui, Bing, Sini, Marcella, Smith, Jeffrey W., Dombrowski, Frank, Calvisi, Diego F., Evert, Matthias, Chen, Xin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280310/
https://ncbi.nlm.nih.gov/pubmed/25145583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27396
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