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Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans
BACKGROUND & AIMS: Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver. METHODS: FASN was over...
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| Publicado no: | J Hepatol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718802/ https://ncbi.nlm.nih.gov/pubmed/26476289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.10.004 |
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