Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

BACKGROUND & AIMS: Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver. METHODS: FASN was over...

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Udgivet i:J Hepatol
Main Authors: Li, Lei, Pilo, Giulia M., Li, Xiaolei, Cigliano, Antonio, Latte, Gavinella, Che, Li, Joseph, Christy, Mela, Marta, Wang, Chunmei, Jiang, Lijie, Ribback, Silvia, Simile, Maria M., Pascale, Rosa M., Dombrowski, Frank, Evert, Matthias, Semenkovich, Clay F., Chen, Xin, Calvisi, Diego F.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718802/
https://ncbi.nlm.nih.gov/pubmed/26476289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.10.004
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