Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

BACKGROUND & AIMS: Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver. METHODS: FASN was over...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Hepatol
Egile Nagusiak: Li, Lei, Pilo, Giulia M., Li, Xiaolei, Cigliano, Antonio, Latte, Gavinella, Che, Li, Joseph, Christy, Mela, Marta, Wang, Chunmei, Jiang, Lijie, Ribback, Silvia, Simile, Maria M., Pascale, Rosa M., Dombrowski, Frank, Evert, Matthias, Semenkovich, Clay F., Chen, Xin, Calvisi, Diego F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718802/
https://ncbi.nlm.nih.gov/pubmed/26476289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.10.004
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