Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

BACKGROUND & AIMS: Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver. METHODS: FASN was over...

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Detaylı Bibliyografya
Yayımlandı:J Hepatol
Asıl Yazarlar: Li, Lei, Pilo, Giulia M., Li, Xiaolei, Cigliano, Antonio, Latte, Gavinella, Che, Li, Joseph, Christy, Mela, Marta, Wang, Chunmei, Jiang, Lijie, Ribback, Silvia, Simile, Maria M., Pascale, Rosa M., Dombrowski, Frank, Evert, Matthias, Semenkovich, Clay F., Chen, Xin, Calvisi, Diego F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718802/
https://ncbi.nlm.nih.gov/pubmed/26476289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.10.004
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