Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, with limited treatment options. AKT/mTOR and Ras/MAPK pathways are frequently deregulated in human hepatocarcinogenesis. Recently, we generated an animal model characterized by the co-expression of activat...

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Main Authors: Wang, Chunmei, Cigliano, Antonio, Delogu, Salvatore, Armbruster, Julia, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737302/
https://ncbi.nlm.nih.gov/pubmed/23759595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25099
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