MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1

Mutations in the neurofibromatosis type 1 (NF1 tumor suppressor gene are common in cancer, and can cause resistance to therapy. Using transcriptome analysis we identified MAF as an NF1 regulated transcription factor, and verified MAF regulation through RAS/MAPK/AP-1 signaling in malignant peripheral...

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Main Authors: Brundage, Meghan E., Tandon, Preeti, Eaves, David W., Williams, Jon P., Miller, Shyra J., Hennigan, Robert H., Jegga, Anil, Cripe, Timothy P., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127377/
https://ncbi.nlm.nih.gov/pubmed/24509877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.506
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