MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1

Mutations in the neurofibromatosis type 1 (NF1 tumor suppressor gene are common in cancer, and can cause resistance to therapy. Using transcriptome analysis we identified MAF as an NF1 regulated transcription factor, and verified MAF regulation through RAS/MAPK/AP-1 signaling in malignant peripheral...

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Main Authors: Brundage, Meghan E., Tandon, Preeti, Eaves, David W., Williams, Jon P., Miller, Shyra J., Hennigan, Robert H., Jegga, Anil, Cripe, Timothy P., Ratner, Nancy
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127377/
https://ncbi.nlm.nih.gov/pubmed/24509877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.506
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