Proper modelling of ligand binding requires an ensemble of bound and unbound states

por Pearce, Nicholas M., Krojer, Tobias, von Delft, Frank
Publicado en Acta Crystallogr D Struct Biol (2017)

per-Alkoxy-pillar[5]arenes as Electron Donors: Electrochemical Properties of Dimethoxy-Pillar[5]arene and Its Corresponding Rotaxane

por Pearce, Nicholas, Davies, E. Stephen, Champness, Neil R.
Publicado en Molecules (2020)

Thionated Perylene Diimide–Phenothiazine Dyad: Synthesis, Structure, and Electrochemical Studies

por Pearce, Nicholas, Davies, E. Stephen, Lewis, William, Champness, Neil R.
Publicado en ACS Omega (2018)

Neuropathogenic SIVsmmFGb Genetic Diversity and Selection-Induced Tissue-Specific Compartmentalization During Chronic Infection and Temporal Evolution of Viral Genes in Lymphoid Ti...

por Reeve, Aaron B., Pearce, Nicholas C., Patel, Kalpana, Augustus, Katherine V., Novembre, Francis J.
Publicado 2010

First identification and characterization of Borrobol‐type tephra in the Greenland ice cores: new deposits and improved age estimates

por Cook, Eliza, Davies, Siwan M., Guðmundsdóttir, Esther R., Abbott, Peter M., Pearce, Nicholas J. G.
Publicado en J Quat Sci (2018)

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

por van den Bos, Ramon M., Pearce, Nicholas M., Granneman, Joke, Brondijk, T. Harma C., Gros, Piet
Publicado en Front Immunol (2019)

Monoclonal antibody against N2 neuraminidase of cold adapted A/Leningrad/134/17/57 (H2N2) enables efficient generation of live attenuated influenza vaccines

por Shcherbik, Svetlana, Carney, Paul, Pearce, Nicholas, Stevens, James, Dugan, Vivien G., Wentworth, David E., Bousse, Tatiana
Publicado en Virology (2018)

Implementation of new approaches for generating conventional reassortants for live attenuated influenza vaccine based on Russian master donor viruses

por Shcherbik, Svetlana, Pearce, Nicholas, Kiseleva, Irina, Larionova, Natalie, Rudenko, Larisa, Xu, Xiyan, Wentworth, David E., Bousse, Tatiana
Publicado en J Virol Methods (2015)

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

por Pearce, Nicholas M., Bradley, Anthony R., Krojer, Tobias, Marsden, Brian D., Deane, Charlotte M., von Delft, Frank
Publicado en Struct Dyn (2017)

Rapid Strategy for Screening by Pyrosequencing of Influenza Virus Reassortants - Candidates for Live Attenuated Vaccines

por Shcherbik, Svetlana V., Pearce, Nicholas C., Levine, Marnie L., Klimov, Alexander I., Villanueva, Julie M., Bousse, Tatiana L.
Publicado 2014

The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination

por Krojer, Tobias, Talon, Romain, Pearce, Nicholas, Collins, Patrick, Douangamath, Alice, Brandao-Neto, Jose, Dias, Alexandre, Marsden, Brian, von Delft, Frank
Publicado en Acta Crystallogr D Struct Biol (2017)

Reduced Genetic Diversity in Lymphoid and Central Nervous System Tissues and Selection-Induced Tissue-Specific Compartmentalization of Neuropathogenic SIVsmmFGb during Acute Infect...

por Reeve, Aaron B., Patel, Kalpana, Pearce, Nicholas C., Augustus, Katherine V., Domingues, Heber G., O'Neil, Shawn P., Novembre, Francis J.
Publicado 2009

Gentle, fast and effective crystal soaking by acoustic dispensing

por Collins, Patrick M., Ng, Jia Tsing, Talon, Romain, Nekrosiute, Karolina, Krojer, Tobias, Douangamath, Alice, Brandao-Neto, Jose, Wright, Nathan, Pearce, Nicholas M., von Delft, Frank
Publicado en Acta Crystallogr D Struct Biol (2017)

Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influ...

por Isakova-Sivak, Irina, Korenkov, Daniil, Smolonogina, Tatiana, Tretiak, Tatiana, Donina, Svetlana, Rekstin, Andrey, Naykhin, Anatoly, Shcherbik, Svetlana, Pearce, Nicholas, Chen, Li-Mei, Bousse, Tatiana, Rudenko, Larisa
Publicado en Virology (2016)

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

por Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S
Publicado en eLife (2018)

Generation and Characterization of Live Attenuated Influenza A(H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation

por Shcherbik, Svetlana, Pearce, Nicholas, Balish, Amanda, Jones, Joyce, Thor, Sharmi, Davis, Charles Todd, Pearce, Melissa, Tumpey, Terrence, Cureton, David, Chen, Li-Mei, Villanueva, Julie, Bousse, Tatiana L.
Publicado en PLoS One (2015)

Evaluation of A(H1N1)pdm09 LAIV vaccine candidates stability and replication efficiency in primary human nasal epithelial cells

por Shcherbik, Svetlana, Pearce, Nicholas, Carney, Paul, Bazhenova, Ekaterina, Larionova, Natalie, Kiseleva, Irina, Rudenko, Larisa, Kumar, Amrita, Goldsmith, Cynthia S., Dugan, Vivien, Stevens, James, Wentworth, David E., Bousse, Tatiana
Publicado en Vaccine X (2019)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

por Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Publicado en Nat Commun (2017)

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

por Oosterheert, Wout, Xenaki, Katerina T, Neviani, Viviana, Pos, Wouter, Doulkeridou, Sofia, Manshande, Jip, Pearce, Nicholas M, Kroon-Batenburg, Loes MJ, Lutz, Martin, van Bergen en Henegouwen, Paul MP, Gros, Piet
Publicado en Life Sci Alliance (2020)

Ten simple rules for surviving an interdisciplinary PhD

por Demharter, Samuel, Pearce, Nicholas, Beattie, Kylie, Frost, Isabel, Leem, Jinwoo, Martin, Alistair, Oppenheimer, Robert, Regep, Cristian, Rukat, Tammo, Skates, Alexander, Trendel, Nicola, Gavaghan, David J., Deane, Charlotte M., Knapp, Bernhard
Publicado en PLoS Comput Biol (2017)