Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model

This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6:2 (NP from MDV) and 5:3 (NP from wild-type virus) genome compositions were compared with regard t...

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Dades bibliogràfiques
Publicat a:Virology
Autors principals: Isakova-Sivak, Irina, Korenkov, Daniil, Smolonogina, Tatiana, Tretiak, Tatiana, Donina, Svetlana, Rekstin, Andrey, Naykhin, Anatoly, Shcherbik, Svetlana, Pearce, Nicholas, Chen, Li-Mei, Bousse, Tatiana, Rudenko, Larisa
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127729/
https://ncbi.nlm.nih.gov/pubmed/27829176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.10.027
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