Reduced Genetic Diversity in Lymphoid and Central Nervous System Tissues and Selection-Induced Tissue-Specific Compartmentalization of Neuropathogenic SIVsmmFGb during Acute Infection

The simian lentivirus strain SIVsmmFGb is a viral swarm population inducing neuropathology in over 90% of infected pigtailed macaques and serves as a reliable model for HIV neuropathogenesis. However, little is understood about the genetic diversity of this virus, how said diversity influences the i...

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Detalhes bibliográficos
Main Authors: Reeve, Aaron B., Patel, Kalpana, Pearce, Nicholas C., Augustus, Katherine V., Domingues, Heber G., O'Neil, Shawn P., Novembre, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853841/
https://ncbi.nlm.nih.gov/pubmed/19500015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2008.0240
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