Mechanism of Recruitment and Activation of the Endosome-associated Deubiquitinase AMSH

Por Davies, Christopher W., Paul, Lake N., Das, Chittaranjan
Publicado em 2013

Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability

Por Davies, Christopher W., Paul, Lake N., Kim, Myung-Il, Das, Chittaranjan
Publicado em 2011

Specificity of HCPTP variants toward EphA2 tyrosines by quantitative selected reaction monitoring

Por Balasubramaniam, Deepa, Paul, Lake N, Homan, Kristoff T, Hall, Mark C, Stauffacher, Cynthia V
Publicado em 2011

Perturbation of the Monomer–Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer

Por Andrews, Forest H., Rogers, Megan P., Paul, Lake N., McLeish, Michael J.
Publicado em 2014

Asymmetric hetero-domain interface stabilizes a response regulator-DNA complex

Por Narayanan, Anoop, Kumar, Shivesh, Evrard, Amanda N, Paul, Lake N., Yernool, Dinesh A.
Publicado no Nat Commun (2014)

Structure-Function Studies of DNA Binding Domain of Response Regulator KdpE Reveals Equal Affinity Interactions at DNA Half-Sites

Por Narayanan, Anoop, Paul, Lake N., Tomar, Sakshi, Patil, Dipak N., Kumar, Pravindra, Yernool, Dinesh A.
Publicado em 2012

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination

Por Sheedlo, Michael J., Qiu, Jiazhang, Tan, Yunhao, Paul, Lake N., Luo, Zhao-Qing, Das, Chittaranjan
Publicado no Proc Natl Acad Sci U S A (2015)

Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis

Por Chen, Chun-Liang, Mermoud, James C., Paul, Lake N., Steussy, Calvin Nicklaus, Stauffacher, Cynthia V.
Publicado no J Biol Chem (2017)

A Conserved Acidic Residue in Phenylalanine Hydroxylase Contributes to Cofactor Affinity and Catalysis

Por Ronau, Judith A., Paul, Lake N., Fuchs, Julian E., Liedl, Klaus R., Abu-Omar, Mahdi M., Das, Chittaranjan
Publicado no Biochemistry (2014)

Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product

Por Shrestha, Rashmi K., Ronau, Judith A., Davies, Christopher W., Guenette, Robert G., Strieter, Eric R., Paul, Lake N., Das, Chittaranjan
Publicado em 2014

Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens

Por Thangamani, Shankar, Mohammad, Haroon, Abushahba, Mostafa F. N., Sobreira, Tiago J. P., Hedrick, Victoria E., Paul, Lake N., Seleem, Mohamed N.
Publicado no Sci Rep (2016)

Wolbachia Endosymbionts Modify Drosophila Ovary Protein Levels in a Context-Dependent Manner

Por Christensen, Steen, Pérez Dulzaides, Ricardo, Hedrick, Victoria E., Momtaz, A. J. M. Zehadee, Nakayasu, Ernesto S., Paul, Lake N., Serbus, Laura R.
Publicado no Appl Environ Microbiol (2016)

Characterization of the Proteome of Cytoplasmic Lipid Droplets in Mouse Enterocytes after a Dietary Fat Challenge

Por D’Aquila, Theresa, Sirohi, Devika, Grabowski, Jeffrey M., Hedrick, Victoria E., Paul, Lake N., Greenberg, Andrew S., Kuhn, Richard J., Buhman, Kimberly K.
Publicado no PLoS One (2015)

Dynamics of an active-site flap contributes to catalysis in a JAMM family metallo deubiquitinase

Por Bueno, Amy N., Shrestha, Rashmi K., Ronau, Judith A, Babar, Aditya, Sheedlo, Michael J., Fuchs, Julian E., Paul, Lake N., Das, Chittaranjan
Publicado no Biochemistry (2015)

An additional substrate binding site in a bacterial phenylalanine hydroxylase

Por Ronau, Judith A., Paul, Lake N., Fuchs, Julian E., Corn, Isaac R., Wagner, Kyle T., Liedl, Klaus R., Abu-Omar, Mahdi M., Das, Chittaranjan
Publicado em 2013

Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process

Por Tsai, Chai-jui, Aslam, Kiran, Drendel, Holli M., Asiago, Josephat M., Goode, Kourtney M., Paul, Lake N., Rochet, Jean-Christophe, Hazbun, Tony R.
Publicado no J Biol Chem (2015)

Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent

Por Thangamani, Shankar, Mohammad, Haroon, Abushahba, Mostafa F. N., Hamed, Maha I., Sobreira, Tiago J. P., Hedrick, Victoria E., Paul, Lake N., Seleem, Mohamed N.
Publicado no Sci Rep (2015)

Synthesis, Characterization, and Evaluation of Pluronic-Based β-Cyclodextrin Polyrotaxanes for Mobilization of Accumulated Cholesterol from Niemann-Pick Type C Fibroblasts

Por Collins, Christopher J., McCauliff, Leslie A., Hyun, Seok-Hee, Zhang, Zhaorui, Paul, Lake N., Kulkarni, Aditya, Zick, Klaus, Wirth, Mary, Storch, Judith, Thompson, David H.
Publicado no Biochemistry (2013)

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

Por Tomar, Sakshi, Johnston, Melanie L., St. John, Sarah E., Osswald, Heather L., Nyalapatla, Prasanth R., Paul, Lake N., Ghosh, Arun K., Denison, Mark R., Mesecar, Andrew D.
Publicado no J Biol Chem (2015)

Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity

Por Morrow, Marie E., Kim, Myung-Il, Ronau, Judith A., Sheedlo, Michael J., White, Rhiannon R., Chaney, Joseph, Paul, Lake N., Lill, Markus A., Artavanis-Tsakonas, Katerina, Das, Chittaranjan
Publicado em 2013