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Dynamics of an active-site flap contributes to catalysis in a JAMM family metallo deubiquitinase
The endosome-associated deubiquitinase (DUB) AMSH is a member of the JAMM family of zinc-dependent metallo isopeptidases with high selectivity for Lys63-linked polyubiquitin chains, which play a key role in endosomal-lysosomal sorting of activated cell surface receptors. The catalytic domain of the...
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| Veröffentlicht in: | Biochemistry |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4962790/ https://ncbi.nlm.nih.gov/pubmed/26368668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00631 |
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