Synthesis, Characterization, and Evaluation of Pluronic-Based β-Cyclodextrin Polyrotaxanes for Mobilization of Accumulated Cholesterol from Niemann-Pick Type C Fibroblasts

[Image: see text] Several lines of evidence suggest that β-cyclodextrin (β-CD) derivatives initiate the efflux of accumulated, unesterified cholesterol from the late endosomal/lysosomal compartment in Niemann Pick C (NPC) disease models. Unfortunately, repeated injections or continuous infusions of...

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Publicado en:Biochemistry
Main Authors: Collins, Christopher J., McCauliff, Leslie A., Hyun, Seok-Hee, Zhang, Zhaorui, Paul, Lake N., Kulkarni, Aditya, Zick, Klaus, Wirth, Mary, Storch, Judith, Thompson, David H.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319568/
https://ncbi.nlm.nih.gov/pubmed/23560535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3010889
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